In 1348, Venice population is halved by the plague. In spite of this, Venice succeeds in becoming the leader of the 4 seapowers of Mediterranean Sea: the other ones were the Republics of Amalfi, Genoa and La Spezia
In 1489 Venice conquers the island of Cyprus.
In 1516 the first Ghetto in the world is founded in Venice.
Another great plague affects Italy in 1630, and for Serenissima Repubblica this is the beginning of the decadence